Published 2026-06-10
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
Ushbu maqolada Silybum marianum L. Gaertn. o‘simligidan olinadigan silimarin kompleksining mitoxondrial funksiya va reaktiv kislorod turlari hosil bo‘lishiga ta’siri zamonaviy biokimyoviy, hujayraviy, hayvon modeli va klinik tadqiqotlar asosida tanqidiy tahlil qilindi. Silimarin tarkibidagi silibin A va B, izosilibinlar, silikristin va silidianinning elektron-transport zanjiri, mitoxondrial membrana potensiali, oksidlovchi fosforlanish, ATP sintezi, kardiolipin barqarorligi, mitoxondrial biogenez, dinamik muvozanat va mitofagiyaga ta’siri umumlashtirildi. Tahlil natijalari silimarinning antioksidant samarasi faqat erkin radikallarni bevosita tutib qolish bilan cheklanmasligini, balki elektronlarning I va III komplekslardan sizib chiqishini kamaytirish, Nrf2/ARE va SIRT3/SOD2 tizimlarini faollashtirish, glutation homeostazini tiklash, mitoxondrial o‘tkazuvchanlik porasining patologik ochilishini cheklash hamda PGC-1α, OPA1 va PINK1/Parkin bilan bog‘liq sifat nazorati mexanizmlarini modulyatsiya qilish orqali yuzaga kelishini ko‘rsatdi. Hujayra va hayvon modellarida membrana potensiali, nafas olish, ATP miqdori va antioksidant fermentlar faolligining yaxshilanishi kuzatilgan bo‘lsa-da, klinik tadqiqotlarda aynan mitoxondrial yakun ko‘rsatkichlar kam o‘lchangan. Silimarinning past bioo‘zlashtirilishi, preparatlar tarkibidagi farqlar va doza bo‘yicha heterogenlik natijalarni translatsiya qilishni cheklaydi. Maqolada “radikal yuk – bioenergetik barqarorlik – mitoxondrial sifat nazorati – hujayraviy natija”dan iborat to‘rt bo‘g‘inli baholash modeli taklif etildi.
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